Skilarence (dimethyl fumarate) is a prescription medication used to treat moderate to severe plaque psoriasis in adults. It is an oral medication that is available in 30 mg and 120 mg tablets.
Uses
Skilarence is used to treat moderate to severe plaque psoriasis in adults. Plaque psoriasis is a chronic autoimmune disease that causes red, scaly patches of skin to form. Skilarence can help to clear these patches and improve the appearance and comfort of the skin.
Storage Conditions
Skilarence should be stored at room temperature, away from heat and moisture.
Mechanism of Action
Skilarence works by reducing inflammation. It is thought to do this by activating glutathione S-transferase (GST), an enzyme that helps to protect cells from damage. GST also helps to break down dimethyl fumarate into monomethyl fumarate, which is the active form of the drug. Monomethyl fumarate inhibits the production of inflammatory cytokines, which are proteins that play a role in the development of psoriasis.
How to Use
Skilarence is taken orally, with or without food. The starting dose is 30 mg once a day. The dose is increased gradually every week until the patient is taking the maximum dose of 240 mg three times a day.
Important Safety Information
Skilarence can cause a number of side effects, including:
- Flushing
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Lymphopenia (low white blood cell count)
- Hepatotoxicity (liver damage)
Skilarence can also increase the risk of serious infections, including tuberculosis. Before starting Skilarence, your doctor will test you for tuberculosis. Skilarence can also reactivate latent tuberculosis infection.
Indications
Skilarence is indicated for the treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
Precautions
Skilarence should be used with caution in patients with a history of serious infections, tuberculosis, liver disease, or lymphopenia.
Skilarence should not be used in patients with a history of hypersensitivity to dimethyl fumarate or any of the other ingredients in Skilarence.
Interactions
Skilarence may interact with other medications, including:
- Methotrexate
- Cyclosporine
- Tacrolimus
- AZA (azathioprine)
- 6-MP (mercaptopurine)
Be sure to tell your doctor about all of the medications you are taking before starting Skilarence.
Contraindications
Skilarence is contraindicated in patients with a history of hypersensitivity to dimethyl fumarate or any of the other ingredients in Skilarence.
Overdose
There is no known overdose of Skilarence. However, if you take more Skilarence than prescribed, be sure to contact your doctor immediately.
Side Effects
The most common side effects of Skilarence are flushing, nausea, vomiting, diarrhea, and abdominal pain. These side effects are usually mild and go away on their own.
More serious side effects of Skilarence include lymphopenia, hepatotoxicity, and serious infections. If you experience any of these side effects, be sure to tell your doctor immediately.
Conclusion
Skilarence is an effective medication for the treatment of moderate to severe plaque psoriasis in adults. It is important to be aware of the potential side effects of Skilarence and to talk to your doctor about whether it is right for you.
Isadora Monteiro –
After trying several different psoriasis treatments, Skilarence has been the one that delivered the best results for me. My plaques have continued to fade, the itching has almost disappeared, and my overall quality of life has improved dramatically. My dermatologist has been very satisfied with my response to treatment, and I couldn’t be happier.
Mikko Lahtinen –
Skilarence has exceeded my expectations. My psoriasis is much better controlled, and my skin feels healthier than it has in years. The improvement has allowed me to enjoy outdoor activities and spend time with friends without feeling self-conscious. I’m incredibly grateful for how effective this medication has been.
Luciana Ribeiro –
Since beginning Skilarence, my skin has continued to improve month after month. The irritation and flaking that once affected my daily life are now minimal. I spend much less time worrying about covering my skin, and I feel more comfortable in social situations. My doctor is pleased with my progress, and so am I.
Connor Gallagher –
I had struggled with psoriasis for years before starting Skilarence. The improvements came gradually, but they were definitely worth the wait. The plaques became much smaller, the itching decreased significantly, and my confidence returned. My follow-up appointments have been very encouraging, and I highly recommend discussing this treatment with a dermatologist.
Nikolina Pavlova –
Skilarence has made a tremendous difference in treating my plaque psoriasis. After several months of treatment, my skin became noticeably clearer, and the persistent redness and scaling gradually faded. My dermatologist has been very pleased with my progress, and I finally feel comfortable wearing short-sleeved shirts again. I’m extremely happy with the results.