Chemical name:(Z)-2-[4-(1,2-Diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine
Formula: C26H29NO
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
TAMOXIFEN-TEVA 10mg – TEVA PHARMACEUTICAL
Product Description:
Tamoxifen-Teva 10mg, manufactured by Teva Pharmaceutical Industries, is a widely-used medication primarily prescribed for the treatment and prevention of breast cancer. Each tablet contains 10mg of Tamoxifen Citrate, a selective estrogen receptor modulator (SERM) that competitively inhibits estrogen binding to estrogen receptors, thereby exerting anti-estrogenic effects in breast tissue.
Mechanism of Action:
Tamoxifen Citrate acts by blocking estrogen receptors in breast tissue, thereby preventing estrogen from binding to these receptors. This mechanism inhibits the growth of estrogen-sensitive cancer cells, which is particularly beneficial in the treatment of estrogen receptor-positive breast cancer.
Indications:
Tamoxifen-Teva 10mg is indicated for:
- Treatment of Breast Cancer: It is used in both premenopausal and postmenopausal women with estrogen receptor-positive breast cancer as an adjuvant therapy after surgery or radiation.
- Reduction of Breast Cancer Risk: Tamoxifen is also prescribed to women at high risk of developing breast cancer to reduce their risk of developing the disease.
Dosage and Administration:
The recommended dose of Tamoxifen-Teva 10mg varies depending on the specific indication and patient characteristics. Typically, it is taken orally as directed by a healthcare provider. Dosage adjustments may be necessary based on individual response and tolerance to the medication.
Contraindications:
Tamoxifen-Teva 10mg should not be used in patients with:
- Known hypersensitivity to Tamoxifen or any components of the formulation.
- History of venous thromboembolic events.
- Pregnancy or lactation.
- Severe hepatic impairment.
Precautions:
- Regular monitoring of liver function tests and blood counts is recommended during treatment.
- Tamoxifen-Teva 10mg may increase the risk of endometrial cancer, thromboembolic events, and other serious side effects.
- It is important to discuss the risks and benefits of Tamoxifen therapy with a healthcare provider before initiating treatment.
Adverse Reactions:
Common side effects of Tamoxifen-Teva 10mg include:
- Hot flashes
- Vaginal discharge
- Nausea
- Fatigue
- Headache
- Fluid retention
Serious adverse reactions such as thromboembolic events, stroke, and uterine malignancies may occur but are less common.
Storage:
Store Tamoxifen-Teva 10mg at room temperature (15-30°C) in a dry place away from light and moisture. Keep out of reach of children and pets.
Conclusion:
Tamoxifen-Teva 10mg from Teva Pharmaceutical is a well-established medication in the management of breast cancer, offering significant benefits in reducing the risk of disease recurrence and improving overall survival rates in patients. It is crucial to adhere strictly to prescribed dosages and guidelines provided by healthcare professionals to maximize therapeutic efficacy and minimize potential risks associated with treatment.
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