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DISEASE INDICATIONS: Primary Biliary Cholangitis (PBC) MANUFACTURER: Novartis USAGE: Oral MEDICINE APPROVED BY: European Medical Agency (EMA) Food and Drug Administration (FDA) Isturisa (osilodrostat) is a cortisol synthesis inhibitor used to treat Cushing's syndrome, a condition in which the body produces too much of the hormone cortisol. It is approved by the US Food and Drug Administration (FDA) for adults with Cushing's disease, a type of Cushing's syndrome caused by a tumor on the pituitary gland, and for adults with endogenous Cushing's syndrome (ECS), a type of Cushing's syndrome caused by the body overproducing cortisol on its own.