Overview:
Tilidin 20x 150/12mg is a powerful analgesic medication manufactured by Sandoz, designed to manage moderate to severe pain. It combines Tilidine, a synthetic opioid, with Naloxone to mitigate the potential for abuse.
Composition:
Active Ingredients:
- Tilidine Hydrochloride: 150 mg
- Naloxone Hydrochloride: 12 mg
Inactive Ingredients:
- Microcrystalline cellulose
- Lactose monohydrate
- Magnesium stearate
- Croscarmellose sodium
- Povidone
- Other excipients for tablet formulation
Mechanism of Action:
Tilidine is a centrally acting opioid analgesic. It works by binding to the opioid receptors in the brain and spinal cord, which alters the perception and response to pain.
Naloxone, an opioid antagonist, is included to counteract the potential euphoric effects of Tilidine, thereby reducing the risk of misuse and addiction. Naloxone acts by blocking the opioid receptors, ensuring that the analgesic effect of Tilidine is achieved without the typical opioid-induced euphoria.
Indications:
Tilidin 20x 150/12mg is indicated for the management of:
- Moderate to severe acute pain
- Chronic pain conditions where other pain management options have been inadequate
- Post-operative pain
Dosage and Administration:
Dosage:
- The typical adult dose is one tablet taken every 6 to 8 hours, as needed for pain relief.
- The maximum daily dose should not exceed four tablets (600 mg of Tilidine and 48 mg of Naloxone).
Administration:
- Tablets should be swallowed whole with a sufficient amount of water.
- Can be taken with or without food.
- Dosage should be adjusted according to the severity of pain and the patient’s response to treatment.
Contraindications:
- Hypersensitivity to Tilidine, Naloxone, or any other component of the product.
- Patients with severe respiratory depression.
- Patients with acute or severe bronchial asthma or hypercapnia.
- Known or suspected gastrointestinal obstruction, including paralytic ileus.
Warnings and Precautions:
- Use with caution in patients with a history of substance abuse or dependency.
- May cause respiratory depression; monitor patients for signs of respiratory distress.
- Caution in patients with head injury or increased intracranial pressure.
- Use with caution in patients with hepatic or renal impairment.
- Avoid abrupt discontinuation; tapering the dose is recommended to prevent withdrawal symptoms.
Potential Side Effects:
Common:
- Nausea
- Vomiting
- Dizziness
- Drowsiness
- Constipation
Serious:
- Respiratory depression
- Severe allergic reactions
- Seizures
- Dependency and withdrawal symptoms upon abrupt discontinuation
Drug Interactions:
- CNS depressants: Increased risk of respiratory depression, sedation.
- MAO inhibitors: Possible severe and unpredictable reactions.
- Serotonergic drugs: Increased risk of serotonin syndrome.
Storage:
- Store at room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep in a tightly closed container, away from moisture and light.
- Keep out of reach of children.
Packaging:
- Each box contains 20 tablets of Tilidin 150/12 mg.
- Blister packs ensure the integrity and freshness of each dose.
Leonard Mercer –
I’ve had a great experience with Tilidin 150/12mg from start to finish. The packaging was discreet, secure, and professionally sealed, and the product quality felt very reliable. I appreciate the trusted reputation of Sandoz and the attention to detail in both manufacturing and presentation. Definitely satisfied with the overall experience.
Anastasia Whitmore –
Excellent product quality and professional packaging. Tilidin 150/12mg arrived in perfect condition and everything looked authentic and well manufactured. The blister packaging makes the tablets easy to manage daily, and the overall design feels premium and secure. Very pleased with this purchase.
Calvin Prescott –
Tilidin 150/12mg exceeded my expectations in terms of quality and presentation. The tablets were packaged neatly, and the labeling was very clear and professional. Sandoz products have always felt dependable to me, and this one maintained the same high standard. The entire purchase experience was smooth and trustworthy. Highly recommended.
Viviana Holloway –
Very impressed with Tilidin 150/12mg. The product arrived fresh and properly sealed, and the blister packs were convenient and easy to organize. Everything about the packaging and presentation felt reliable and professionally manufactured. I also appreciated the smooth ordering and delivery process. Excellent overall experience.
Emmett Carlisle –
Tilidin 150/12mg arrived securely packaged and exactly as described. The tablets were clearly labeled, and the overall presentation looked professional and authentic. I appreciate the trusted manufacturing standards from Sandoz, and the packaging quality gave me confidence in the product. Shipping was discreet and efficient as well. Very satisfied overall.