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Buy Spedra 100mg Tablets Avanafil Online

Product: Spedra 4x 100mg

Active substance: Avanafil

Manufacturer / Brand: Berlin-Chemie AG

From $51.24

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SKU:926835

Introduction

Spedra (Avanafil) is a potent medication used to treat erectile dysfunction (ED) in men. Manufactured by Berlin-Chemie AG, Spedra is known for its rapid onset of action and efficacy. This medication belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors, which work by enhancing blood flow to the penis, thereby facilitating and maintaining an erection during sexual stimulation.

Active Substance

The active substance in Spedra is Avanafil. Each tablet contains 100 mg of Avanafil, a highly selective inhibitor of the PDE5 enzyme. Avanafil’s selectivity allows for fewer side effects and a more favorable safety profile compared to other PDE5 inhibitors.

Mechanism of Action

Avanafil works by inhibiting the PDE5 enzyme, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the penile tissue. During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum, leading to an increase in cGMP levels. Elevated cGMP levels cause the smooth muscles in the penile arteries to relax, allowing increased blood flow into the penis. This process results in an erection. By blocking PDE5, Avanafil prolongs the presence of cGMP, thereby enhancing and sustaining an erection.

Indications

Spedra is indicated for the treatment of erectile dysfunction in adult men. It is effective for men who have difficulty achieving or maintaining an erection sufficient for satisfactory sexual performance. The medication is to be used only when sexual activity is anticipated and is not intended for continuous daily use.

Dosage and Administration

The recommended starting dose of Spedra is 100 mg, taken as needed approximately 15-30 minutes before sexual activity. Based on individual efficacy and tolerability, the dose may be increased to a maximum of 200 mg or decreased to 50 mg. Spedra can be taken with or without food; however, a high-fat meal may delay its onset of action. It is important not to exceed one dose per day.

Onset of Action and Duration

One of the key advantages of Spedra is its rapid onset of action. Clinical studies have shown that Avanafil can start working in as little as 15 minutes after ingestion. The effects of Spedra can last up to 6 hours, providing a substantial window for spontaneous sexual activity.

Clinical Efficacy

Clinical trials have demonstrated the efficacy of Spedra in improving erectile function. In randomized, double-blind, placebo-controlled studies, a significant proportion of men treated with Spedra achieved successful intercourse compared to those receiving a placebo. The medication has shown consistent results across different populations, including men with diabetes and those with severe ED.

Safety Profile

Spedra is generally well-tolerated. The most common side effects are mild to moderate and include headache, flushing, nasal congestion, and back pain. These side effects are typically transient and resolve on their own. Spedra has a lower incidence of visual disturbances and muscle pain compared to other PDE5 inhibitors.

Precautions and Contraindications

Spedra should not be used in men who are allergic to Avanafil or any of its components. It is contraindicated in patients taking nitrates or nitric oxide donors, as the combination can lead to a severe drop in blood pressure. Caution is advised in patients with cardiovascular disease, liver or kidney impairment, and those predisposed to priapism. Men advised against sexual activity due to health reasons should not use Spedra.

Drug Interactions

Avanafil can interact with certain medications, potentially altering its effectiveness or increasing the risk of adverse effects. Key interactions include:

  • Nitrates: Concomitant use can cause severe hypotension.
  • Alpha-blockers: Can lead to symptomatic hypotension; if used together, stable doses should be established.
  • Strong CYP3A4 inhibitors: Such as ketoconazole and ritonavir, can increase Avanafil levels; dose adjustments are necessary.
  • Alcohol: Excessive alcohol consumption can increase the likelihood of side effects such as dizziness and hypotension.

Special Populations

Elderly

No dose adjustment is necessary for elderly patients; however, they may be more sensitive to the effects of Spedra.

Renal Impairment

In patients with mild to moderate renal impairment, no dose adjustment is required. Spedra is not recommended for use in severe renal impairment.

Hepatic Impairment

For patients with mild to moderate hepatic impairment, the starting dose should be 50 mg. Spedra is not recommended for use in severe hepatic impairment.

Storage

Spedra should be stored at room temperature, away from moisture and heat. Keep out of reach of children and pets.

Conclusion

Spedra (Avanafil) 100 mg is a highly effective and fast-acting medication for the treatment of erectile dysfunction. With its favorable safety profile and rapid onset, it offers a reliable option for men seeking an effective solution to ED. Manufactured by Berlin-Chemie AG, Spedra provides the confidence and spontaneity needed for a fulfilling sexual experience. Always consult a healthcare professional before starting any new medication to ensure it is appropriate for your individual health condition.

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