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Buy Orkambi (lumacaftor/ivacaftor) Online

DISEASE INDICATIONS: Cystic Fibrosis

MANUFACTURER: Vertex Pharmaceuticals (Europe) Ltd

USAGE: Oral

MEDICINE APPROVED BY:

European Medical Agency (EMA)

Food and Drug Administration (FDA)

Therapeutic Goods Administration (TGA)

This medication is designed to address the underlying cause of CF in individuals who have two copies of the F508del mutation in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, which is a common genetic mutation associated with CF.

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Orkambi is a pharmaceutical medication that combines two active ingredients, lumacaftor and ivacaftor, to treat a specific genetic disorder known as cystic fibrosis (CF). This medication is designed to address the underlying cause of CF in individuals who have two copies of the F508del mutation in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, which is a common genetic mutation associated with CF.

Here is a detailed description of Orkambi, which is essentially a combination of lumacaftor and ivacaftor:

Name: Orkambi (Combination of Lumacaftor and Ivacaftor)

Active Ingredients:

  1. Lumacaftor: Lumacaftor is a CFTR corrector medication. It works by assisting the defective CFTR protein in the cells of the respiratory system to fold correctly and move to the cell surface. This allows the CFTR protein to function more effectively in regulating the flow of salt and fluids in and out of the cells, which helps improve mucus clearance and reduces the buildup of thick, sticky mucus in the airways.
  2. Ivacaftor: Ivacaftor is a CFTR potentiator medication. It enhances the function of the CFTR protein that has reached the cell surface, increasing chloride ion transport. This further improves airway surface hydration and reduces the thickness of mucus, making it easier to clear.

Indications: Orkambi is specifically indicated for the treatment of cystic fibrosis in patients who are homozygous for the F508del mutation in the CFTR gene. This mutation is one of the most common genetic causes of CF, and Orkambi is designed to address the underlying genetic defect in individuals with this mutation.

Dosage Forms: Orkambi is typically available in the form of oral tablets or granules, which are taken by mouth.

Usage: The dosing and administration of Orkambi are determined by a healthcare provider and are based on the patient’s age and weight. It is generally taken as prescribed, usually twice daily with fat-containing food to optimize absorption.

Benefits: Orkambi offers the potential to improve lung function, reduce respiratory symptoms, and enhance the overall quality of life for individuals with cystic fibrosis who have the F508del mutation. While it is not a cure for CF, it can help manage the underlying genetic defect and improve the patient’s health and well-being.

Precautions: Patients should undergo genetic testing to determine if they have the specific F508del mutation that Orkambi is designed to treat. It is crucial to use Orkambi as directed by a healthcare provider and to be aware of potential side effects and drug interactions.

Side Effects: Common side effects of Orkambi may include respiratory symptoms such as shortness of breath, cough, and chest tightness. Other possible side effects can include abdominal pain, diarrhea, and elevated liver enzymes. Patients should discuss any side effects or concerns with their healthcare provider.

In conclusion, Orkambi (lumacaftor/ivacaftor) is a combination medication used to treat cystic fibrosis in individuals with the F508del mutation. It addresses the underlying genetic defect to improve lung function and reduce respiratory symptoms associated with CF. Patients should use it as directed by their healthcare provider and be aware of potential side effects and precautions associated with its use.

Package

112 tablets of 100 mg/125 mg, 112 tablets of 200 mg/125 mg

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