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DISEASE INDICATIONS: phenylketonuria (PKU) MANUFACTURER: BioMarin Pharmaceutical Inc. USAGE: Subcutaneous MEDICINE APPROVED BY: European Medical Agency (EMA) Food and Drug Administration (FDA) Palynziq (pegvaliase-pqpz) is a prescription medication used to lower blood levels of phenylalanine (Phe) in adults with phenylketonuria (PKU) who have uncontrolled blood Phe levels above 600 micromol/L (10 mg/dL) on their current treatment. PKU is a rare genetic disorder that prevents the body from breaking down the amino acid phenylalanine. Phenylalanine can build up in the blood and cause serious health problems, such as intellectual disability, seizures, and behavioral problems.