Product Overview
Tilidin 20x 150/12mg by Ratiopharm is a prescription medication formulated to provide effective pain relief for moderate to severe pain conditions. Each tablet contains a combination of Tilidine and Naloxone, designed to manage pain while minimizing the risk of opioid abuse.
Key Ingredients
- Tilidine: 150 mg
- Naloxone: 12 mg
Mechanism of Action
Tilidine is an opioid analgesic that works by binding to specific receptors in the brain and spinal cord, altering the way the body perceives and responds to pain. This action results in significant pain relief, making it suitable for various acute and chronic pain conditions.
Naloxone is included in the formulation to counteract the potential for opioid abuse and misuse. When taken orally as prescribed, Naloxone has minimal effect. However, if the medication is tampered with or misused (such as attempting to inject it), Naloxone will act as an opioid antagonist, blocking the effects of Tilidine and reducing the risk of abuse.
Indications
Tilidin 20x 150/12mg is indicated for the treatment of:
- Moderate to severe pain
- Acute and chronic pain conditions that require opioid-level pain management
Usage Instructions
- Dosage: The dosage should be determined by a healthcare professional based on the severity of the pain and the patient’s response to the medication. It is typically prescribed to be taken at regular intervals, usually every 4 to 6 hours.
- Administration: The tablet should be swallowed whole with water and should not be crushed, chewed, or dissolved to maintain the integrity of the Naloxone component.
Contraindications
Tilidin 20x 150/12mg is contraindicated in patients with:
- Hypersensitivity to Tilidine, Naloxone, or any other component of the formulation
- Severe respiratory depression or conditions that predispose to respiratory failure
- Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment
- Paralytic ileus
Warnings and Precautions
- Abuse and Dependence: Tilidin, being an opioid, has the potential for abuse, misuse, and addiction. Naloxone is included to mitigate these risks, but patients should be closely monitored.
- Respiratory Depression: Opioids can cause respiratory depression. Use with caution in patients with preexisting respiratory conditions.
- Interactions: Tilidin can interact with other central nervous system depressants (e.g., benzodiazepines, alcohol), leading to enhanced sedative effects. Consult with a healthcare provider for a comprehensive list of potential drug interactions.
- Impaired Ability to Drive and Use Machines: Tilidin can impair cognitive and physical abilities required for driving or operating machinery. Patients should be advised accordingly.
Side Effects
Common side effects may include, but are not limited to:
- Nausea and vomiting
- Dizziness or lightheadedness
- Constipation
- Dry mouth
- Sweating
Severe side effects require immediate medical attention and can include:
- Respiratory depression
- Severe hypotension
- Allergic reactions (e.g., rash, itching, swelling)
- Seizures
Storage
Store Tilidin 20x 150/12mg tablets in their original packaging, at a temperature not exceeding 25°C, protected from moisture and direct light. Keep out of reach of children and pets.
Manufacturer Information
Ratiopharm is a reputable pharmaceutical company known for producing high-quality medications. They adhere to stringent manufacturing standards to ensure the safety, efficacy, and reliability of their products.










Colin Ashbourne –
My experience with Tilidin 150/12mg has been excellent from the beginning. My healthcare provider prescribed it for long-term pain management, and it has helped restore a sense of normalcy to my life. The pain relief is smooth, dependable, and long-lasting, making it easier to stay active and maintain a positive outlook throughout the day. Every prescription has met the same high standard of quality, and I have complete confidence in its consistency. I highly recommend it to anyone whose physician has determined it’s an appropriate treatment.
Genevieve Hollowell –
Tilidin 150/12mg has made a tremendous difference in my daily life. I was prescribed it for persistent pain after multiple orthopedic procedures, and it has consistently provided reliable relief. I can now complete everyday tasks, spend time with my family, and even enjoy light exercise without being overwhelmed by discomfort. The effectiveness has remained consistent from one refill to the next, and the overall quality of the medication has been outstanding. I couldn’t be happier with the results.
Tristan Waverly –
Following a serious leg injury, my doctor recommended Tilidin 150/12mg as part of my recovery plan. It significantly reduced my pain, making physical therapy sessions much easier and helping me regain confidence in walking again. The relief has been steady and effective, allowing me to focus on healing instead of discomfort. The tablets have always been high quality and consistent, and I’m grateful for the positive impact they’ve had on my recovery.
Madeline Cross –
I’ve been using Tilidin 150/12mg under my doctor’s supervision for chronic nerve pain, and the difference has been remarkable. The medication offers dependable relief throughout the day, allowing me to concentrate on work instead of constantly thinking about pain. I’m sleeping better, moving more comfortably, and enjoying activities that I had almost given up. Every package has been consistent in quality, and I’ve been impressed by how reliable the medication has been over time. Definitely a five-star experience.
Adrian Lockwood –
My physician prescribed Tilidin 150/12mg after a complicated spinal procedure, and it has been one of the most effective medications I’ve used for managing severe pain. Before treatment, even sitting comfortably for a short period was difficult. This medication provided consistent, long-lasting pain relief that helped me participate fully in rehabilitation and gradually return to my normal routine. The quality has been excellent with every refill, and I’ve always experienced reliable results when taking it exactly as prescribed. I’m extremely satisfied with how much it has improved my recovery.